Well, would be the “Amen Break” from the 1969 song “Amen, Brother” by the Winstons. It’s so famous it has its own wiki entry.Yes, you’ve heard it, thousands of times. Many composers have borrowed it in many genres. It’s a 6-second drum solo which got sampled and became very popular in hip hop in the late 80s, and then in the UK jungle and D&B scene in the 90s.
A fellow named Nate Harrison created a video about it which is now on YouTube, showing the history of the sample, with a number of very interesting musical examples, including NWA’s “Straight Outta Compton”, leading up to increasingly crazy recut versions of the beat in various jungle tunes.
After 11 minutes or so the video goes into meditations on copyright and ownership, etc, which is still mildly interesting, but the musical examples are all before the 12th minute of the video: